James J Lah Selected Research

Amyloid (Amyloid Fibrils)

4/2024	Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.
2/2024	Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease.
2/2024	Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease.
1/2024	APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology.
10/2023	Proteomic Network Analysis of Alzheimer's Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment.
1/2023	Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
1/2023	Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease.
11/2022	CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels.
1/2022	Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease.
1/2022	Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey.

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James J Lah Research Topics

Disease

93	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 05/2003
30	Cognitive Dysfunction 04/2024 - 02/2006
19	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2024 - 01/2006
11	Dementia (Dementias) 02/2024 - 02/2016
10	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2013 - 11/2009
9	Amyloid Plaque 05/2024 - 08/2004
8	Inflammation (Inflammations) 03/2024 - 01/2017
8	Parkinson Disease (Parkinson's Disease) 01/2024 - 01/2012
7	Neuroinflammatory Diseases 04/2024 - 01/2017
6	Disease Progression 01/2020 - 12/2010
4	Tauopathies 05/2024 - 01/2018
4	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 03/2010
2	Amyloid angiopathy 05/2024 - 01/2022
2	Hypercholesterolemia 03/2024 - 01/2019
2	Pathologic Processes 01/2023 - 11/2022
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2012 - 04/2010
2	TDP-43 Proteinopathies 01/2012 - 04/2010
1	Vascular Remodeling 11/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Hypotension (Low Blood Pressure) 01/2022
1	Hyperkalemia 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Atrophy 01/2022
1	Edema (Dropsy) 07/2021
1	Intracranial Arteriosclerosis (Cerebral Atherosclerosis) 01/2020
1	Chronic Traumatic Encephalopathy 01/2018

Drug/Important Bio-Agent (IBA)

54	Proteins (Proteins, Gene)FDA Link 05/2024 - 05/2003
29	Biomarkers (Surrogate Marker)IBA 05/2024 - 08/2004
23	Amyloid (Amyloid Fibrils)IBA 04/2024 - 05/2003
16	ProteomeIBA 02/2024 - 08/2004
11	Apolipoproteins E (ApoE)IBA 03/2024 - 06/2006
8	Peptides (Polypeptides)IBA 04/2024 - 12/2010
8	ApolipoproteinsIBA 01/2024 - 08/2004
8	Amyloid beta-PeptidesIBA 01/2021 - 05/2003
7	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2013 - 03/2010
6	Detergents (Detergent)IBA 01/2021 - 11/2009
6	UbiquitinIBA 10/2018 - 10/2007
5	Particulate MatterIBA 04/2024 - 04/2023
5	RNA (Ribonucleic Acid)IBA 01/2022 - 05/2012
5	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021 - 01/2012
4	LipidsIBA 01/2021 - 01/2008
4	Protein AggregatesIBA 10/2018 - 11/2009
4	U1 Small Nuclear RibonucleoproteinIBA 01/2018 - 10/2013
3	gantenerumabIBA 04/2024 - 07/2021
3	solanezumabIBA 04/2024 - 07/2021
3	Carrier Proteins (Binding Protein)IBA 02/2024 - 02/2015
3	Phosphotransferases (Kinase)IBA 01/2021 - 12/2010
2	chemotactic factor inactivatorIBA 03/2024 - 01/2022
2	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 10/2023 - 01/2022
2	tau Proteins (tau Protein)IBA 10/2023 - 01/2023
2	EndocannabinoidsIBA 01/2023 - 01/2021
2	SugarsIBA 01/2023 - 01/2020
2	Bile Acids and Salts (Bile Acids)IBA 01/2023 - 01/2021
2	SteroidsIBA 01/2023 - 01/2021
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2023 - 01/2021
2	OxylipinsIBA 01/2023 - 01/2021
2	Epoxide HydrolasesIBA 01/2023 - 01/2021
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 01/2018
2	CholesterolIBA 01/2019 - 01/2008
2	IsotopesIBA 01/2019 - 05/2012
2	sarkosylIBA 12/2016 - 12/2014
2	Threonine (L-Threonine)FDA Link 02/2015 - 11/2013
2	Small Nuclear Ribonucleoproteins (snRNP)IBA 12/2014 - 04/2014
2	Nuclear Proteins (Protein, Nuclear)IBA 07/2013 - 08/2012
2	SynucleinsIBA 06/2013 - 04/2012
2	DNA (Deoxyribonucleic Acid)IBA 11/2011 - 12/2010
2	PolyubiquitinIBA 03/2011 - 04/2010
2	LDL Receptors (LDL Receptor)IBA 02/2011 - 08/2004
2	thioflavin TIBA 01/2006 - 08/2004
1	CreatinineIBA 04/2024
1	Heparin (Liquaemin)FDA LinkGeneric 02/2024
1	Angiotensin Receptor AntagonistsIBA 01/2022
1	candesartanIBA 01/2022
1	OsteoprotegerinIBA 01/2022
1	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 01/2022
1	Air Pollutants (Pollutants, Air)IBA 01/2022
1	CytokinesIBA 01/2022
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	Mitogen-Activated Protein KinasesIBA 06/2021
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	TabletsIBA 01/2021
1	moesinIBA 01/2020
1	microtubule-associated protein 1B (MAP5)IBA 01/2020
1	ELAV-Like Protein 2IBA 01/2020
1	MicroRNAs (MicroRNA)IBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Arginine (L-Arginine)FDA Link 01/2019
1	LDL CholesterolIBA 01/2019
1	Apolipoproteins B (ApoB)IBA 01/2019
1	DSP 4 (DSP-4)IBA 01/2018
1	DipeptidesIBA 01/2018
1	NeurotoxinsIBA 01/2018
1	Potassium Channels (Potassium Channel)IBA 01/2017
1	Complement Factor H (Factor H)IBA 02/2016
1	Complement C3 (C3 Complement)IBA 02/2016
1	Presenilin-1IBA 01/2016

Therapy/Procedure

6	Therapeutics 10/2023 - 11/2009
3	Lasers (Laser) 01/2011 - 08/2004
1	Ligation 11/2022